Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development

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Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development.

Type III collagen is a fibrillar forming collagen comprising three alpha1(III) chains and is expressed in early embryos and throughout embryogenesis. In the adult, type III collagen is a major component of the extracellular matrix in a variety of internal organs and skin. Mutations in the COL3A1 gene have been implicated as a cause of type IV Ehlers-Danlos syndrome, a disease leading to aortic ...

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Collagen type I, collagen type III, and versican in vocal fold lamina propria.

OBJECTIVE To analyze the distributions of collagen type I, collagen type III, and versican in the lamina propria of the human vocal fold. DESIGN Cross-sectional analysis of cadaveric vocal folds of adult human larynges. SETTING Academic tertiary referral center. SUBJECTS Larynges harvested at autopsy from 10 adult men and 10 adult women. MAIN OUTCOME MEASURES Immunohistochemical reactio...

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Type I collagen fibrillogenesis in vitro. Additional evidence for the assembly mechanism.

The intensity of scattered light at angles between 30 degrees and 120 degrees has been measured during the heat gelation lag phase of rat tail tendon collagen. As previously reported, the intensity at a scattering angle of 90 degrees does not change during the lag phase of gelation, whereas during this period, the intensity extrapolated to zero degrees more than doubles. Based on measurement of...

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Collagen fibrillogenesis in vitro: interaction of types I and V collagen regulates fibril diameter.

The small-diameter fibrils of the chick corneal stroma are heterotypic, composed of both collagen types I and V. This tissue has a high concentration of type V collagen relative to other type I-containing tissues with larger-diameter fibrils, suggesting that heterotypic interactions may have a regulatory role in the control of fibril diameter. The interactions of collagen types I and V were stu...

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Development of tendon structure and function: regulation of collagen fibrillogenesis.

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1997

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.94.5.1852